Friday, March 20, 2020

This ~might~ explain the collapsing videos.

I have only seen one person say this. And we don't believe anything until we see it confirmed by a few people. Right?

Personally I was pretty confused by the videos I saw because if you were that sick - why would you collapse in the middle of a road for instance. But if they had a super higher fever, maybe they were not in their right minds. No pun intended.

You can read his full timeline here.


  1. Wow!

    Too sick for us, stay home is what it sounded like...

  2. Capital of Texas RefugeeFriday, March 20, 2020 6:55:00 PM

    Ibuprofen acts via the CYP2C9 pathway in the liver.

    Acetaminophen/paracetamol acts via the liver as well through the CYP2E1 and CYP3A4 pathways, so it works differently.

    Certain blood thinners such as warfarin and some coumarins work via the CYP2C9 pathway as well.

    But that can't be all that's involved with this.

    Up-regulation of arachidonic acid is also involved with CYP2C9, and that's part of the set of metabolic processes involving COX and COX2 that are part of the angiotensin-renin processes that are also regulated by ACE2.

    One interesting thing about this is that high potassium levels might promote the same kind of vasodilation that I'd mentioned could be induced with an IV bag or two of norepinephrine ...

    It's interesting because one suggested treatment involves administering soluble ACE2 in order to stimulate the virus to attach to it without having a cell to enter, but another way to stimulate ACE2 production would be to boost intra-cellular K+ levels.

    Balancing potassium with zinc/magnesium, calcium/magnesium, and so forth is really tricky, BTW -- crampy shit happens when you're even barely outside the tolerated range, and then it proceeds to cold extremities, numb fingers, etc.

    I really, really do not like the habit of American doctors thinking that they have to boost K+ levels in isolation from everything else because they have fucking stupid "best practices in medicine" to follow that would also lead to other deficiencies, so I'm normally resistant to this idea, but ...

    Maybe one 99 mg capsule of potassium asporotate per day can't hurt?

  3. Capital of Texas RefugeeFriday, March 20, 2020 6:59:00 PM

    Hmmm ... scratch that.

    It's also possible the body's being flooded by K+ already because the pathogen works in a way that causes a release of K+ like what happens to severe physical injury patients or diabetics undergoing some sort of mild septic shock.

    Excessive vasodilation might also lead to sudden collapses as well.

    So let's see if anyone has figures about absurdly high potassium levels in conjunction with some of these patients.

  4. Also, I've had pneumonia, and you can go from "hey, I don't feel half bad" to, "shit, I just climbed one flight of stairs, I'm going to lay down right here and take a nap now" in about 5 minutes. Not an exaggeration. Not being able to breathe properly knocks you on your ass even if you don't have any other symptoms. Add in the confusion a high fever causes, and yup, the random public collapses don't actually surprise me.

  5. Oh. huh. Interesting. And good to know!

  6. Last time I had pneumonia I was living in the dorm at college (so, 20yrs ago, ugh). I managed to pick up both pneumonia AND the flu at the same freaking time. Neither was bad enough for hospitalization, but they'd caught hte flu early enough that they were able to give me Tammiflu. Took about 3 days for that to knock back most of the flu symptoms. But it was another 2 weeks before just going down to the cafeteria for food didn't result in me sleeping till it was time for the next meal. And it was another week after that before I was able to make it to all my classes. Pneumonia sucks under the best of conditions.